Indian Institute of Technology Madras
BS Degree Programme · Examination & Study Paper
Algorithmic Thinking in Bioinformatics
Quiz 2 · 3 Aug 2025 (Afternoon)
Examination Instructions & Guidelines
- Solve on notebook/paper first before checking solutions.
- MCQ: Exactly 1 option is correct. Negative marking applies.
- MSQ: One or more options correct. Select all to score.
- NAT: Numerical response. No negative marking.
- Scientific calculator allowed for all calculations.
- Official answer key is sealed at the end of this sheet.
- Q1MCQ5 Marks·Choose one option

- AFigure I: Gibbs Sampling; Figure II: Randomized Motif Search; Figure III: Greedy Motif Search
- BFigure I: Gibbs Sampling; Figure II: Greedy Motif Search; Figure III: Randomized Motif Search
- CFigure I: Greedy Motif Search; Figure II: Randomized Motif Search; Figure III: Gibbs Sampling
- DFigure I: Randomized Motif Search; Figure II: Gibbs Sampling; Figure III: Greedy Motif Search
- Q2MCQ3 Marks·Choose one option

- A

- B

- C

- D

- A
- Q3MCQ3 Marks·Choose one option

- A

- B

- C

- D

- A
- Q4MCQ2 Marks·Choose one option

- A

- B

- C

- D

- A
- Q5MCQ2 Marks·Choose one option

- A

- B

- C

- D

- A
- Q6MSQ3 Marks·Choose all correct options
Which of the following statements about additive distance matrices are true?
- AEvery 3 x 3 distance matrix is additive.
- BEvery 4 x 4 distance matrix is additive.
- CThere exists a 3 x 3 distance matrix that is not additive.
- DThere exists a 4 x 4 distance matrix that is not additive.
- EFor every additive distance matrix, there exists a simple tree fitting the matrix.
- Q7NAT3 Marks·Write the number
Your answer: - Q8NAT4 Marks·Write the number
Your answer: Read the passage below, then answer Q9–Q11
Q9NAT3 Marks·Write the numberWhat is the number of edges in the corresponding suffix trie? Enter the value as a single integer.
Your answer:- Q10NAT2 Marks·Write the number
What is the length of the reference sequence from which this suffix tree has been constructed? Include $ in the calculation of length. Enter the value as a single integer.
Your answer: - Q11MCQ3 Marks·Choose one option
Use the given suffix tree to determine which of the following is the suffix array for the reference sequence ? Assume $ comes first in the alphabet.
- A[7, 6, 5, 3, 1, 4, 2, 0]
- B[7, 6, 5, 3, 1, 4, 0, 2]
- C[7, 5, 3, 1, 6, 4, 2, 0]
- D[7, 5, 3, 1, 6, 4, 0, 2]
- ENone of these
Read the passage below, then answer Q12–Q14
Q12MCQ2 Marks·Choose one optionFind the consensus of the motifs?
- ATCATGA
- BAACCGT
- CTCTAAA
- DTCATAA
- Q13NAT2 Marks·Write the number
Your answer: - Q14NAT4 Marks·Write the number
Calculate the entropy of the first column. Round up the answer to 3 decimal places.
Your answer: Read the passage below, then answer Q15–Q16
Q15MCQ5 Marks·Choose one option
- A

- B

- C

- D

- A
- Q16MCQ4 Marks·Choose one option
Which of the following represents the distance matrix for the next iteration?
- A

- B

- C

- D

- A
Read the passage below, then answer Q17–Q18
Q17MCQ2 Marks·Choose one option
- A

- B

- C

- D

- A
- Q18MCQ1 Mark·Choose one option

- A

- B

- C

- D

- E

- A